The current research in the Goldstein laboratory is organized around two important ares of investigation:
1. Defining the factors that enable susceptibility of normal prostate cells to initiate cancer
What is the role of aging?
What is the role of germline genetic variants that increase disease risk?
What is the role of lineage or progenitor state?
What is the ideal metabolic state to support transformation?
What genes/pathways restrain cancer initiation?
2. Elucidating how metabolism is regulated/rewired in prostate cancer
What is the role of the disease-initiating somatic driver genes?
What is the role of lineage identity?
What is the role of the metastatic environment?
What is the role of mitochondrial fuel preference?
Can targeting metabolism halt tumor progression or treatment resistance?
